报告题目：Regioselective Rapid Synthesisof Fully Substituted 1,2,3-TriazolesMediated by Propargyl Cations
Azide-Alkyne Cycloadditions to produce 1,2,3-triazoles have been widely developed since the copper-catalyzed conditions were reported.Due to the efficiency of triazoles for ligands, pharmaceuticals and chemical biology research, many groups have reported mild, rapid, and Copper-free synthetic method.
We have developed the novel synthetic method to generate the fully substituted 1,2,3-triazoles from propargyl cation and organic azides, and most of the reaction can becompletedin 5min. Compared to classical azide-alkyne cycloaddition reactions, our strategy could utilize both terminal and internal alkynes not only at room temperature but also -90 °C. We also conducted various types of three-component reactionswithalcohols, amines, thiol and azide. With suitable nucleophile, C-C bond formations were also achieved. Controlling the reagents and the reactivities of substrates, two different azides were successfully introduced by double [3+2] cycloaddition.