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Regioselective Rapid Synthesis of Fully Substituted 1,2,3-Triazoles Mediated by Propargyl Cations
2014-03-05 10:05:01   审核人:   (点击: )

报告题目:Regioselective Rapid Synthesisof Fully Substituted 1,2,3-TriazolesMediated by Propargyl Cations

报告人:张欢博士日本奈良先端科学技术大学院大学

报告时间:201437日(周五)下午2:00

报告地点:19-226

内容简介:

Azide-Alkyne Cycloadditions to produce 1,2,3-triazoles have been widely developed since the copper-catalyzed conditions were reported.Due to the efficiency of triazoles for ligands, pharmaceuticals and chemical biology research, many groups have reported mild, rapid, and Copper-free synthetic method.

We have developed the novel synthetic method to generate the fully substituted 1,2,3-triazoles from propargyl cation and organic azides, and most of the reaction can becompletedin 5min. Compared to classical azide-alkyne cycloaddition reactions, our strategy could utilize both terminal and internal alkynes not only at room temperature but also -90 °C. We also conducted various types of three-component reactionswithalcohols, amines, thiol and azide. With suitable nucleophile, C-C bond formations were also achieved. Controlling the reagents and the reactivities of substrates, two different azides were successfully introduced by double [3+2] cycloaddition.

 

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